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Steroids, for example, just globally suppress the immune system and have a whole range of nasty side effects like weight gain, nutrient deficiencies, and increased susceptibility to infections

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This receptor interaction triggers intracellular signalling cascades, primarily the PI3K-AKT and MAPK pathways (1)

Abbreviations APAP : Acetaminophen GJ : Gap-junction NAC : N-acetylcysteine GSH : Glutathione NAPQI : N-acetyl-p-benzoquinone imine ROS : Reactive oxygen species Nrf2 : Nuclear factor E2-related factor 2 Cx32 : Connexin 32 TTSP : Type II transmembrane serine protease HGF : Hepatocyte growth factor References Chiew AL, Isbister GK